Pharmaceutical Structure Confirmation Using Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy Proof of Structure – Clindamycin
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چکیده
Two of the key spectroscopic techniques used to accomplish this task are mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). These methods provide a wealth of complementary structural information. Mass spectrometry is used to determine the molecular formula for a given compound and can provide structural information through MSn analysis. Nuclear magnetic resonance spectroscopy is used to determine the type and connectivity of individual atoms within a structural framework. When used in an integrated fashion, these techniques can unambiguously establish the chemical identity of a pharmaceutical compound.
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Pharmaceutical Structure Confirmation Using Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy Proof of Structure – Clindamycin Authors
This note investigates the structure of clindamycin in an integrated fashion using an Agilent 500 Ion Trap LC/MS and an Agilent 400-MR NMR spectrometer. The data allows for the rapid confirmation of the chemical structure. Introduction One of the basic spectroscopic tasks widely performed in the pharmaceutical industry is confirmation of structure for a known compound. This is a critically impo...
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